Angiogenin2 and MiR-211 protein expression in gastric cancer tissue sample and its relationship with the prog-nosis

MAI Cong; TANG Yun-qiang; ZHAO Hong-yu; TU Yi-nuo

doi:10.3969/j.issn.1001-9448.2017.02.013

Abstract：Objective To investigate the angiogenin sample protein 2 ( ANGPTL2 ) and miR-211 protein ex-pression level in gastric cancer tissue sample and its relationship with the prognosis .Methods Immunohistochemical method was applied to detect ANGPTL 2 and miR-211 protein expression level in the gastric cancer tissue and its corre-sponding tissue adjacent to carcinoma from 62 patients with gastric cancer and gastric cancer radical treatment in our hospi -tal.And effect of the above factors on the prognosis of patients was analyzed .Results ANGPTL2 and miR-211 protein positive rate in gastric cancer tissue were 88.71%and 83.87%, respectively , which were significantly higher than normal tissues adjacent to carcinoma (3.23%and 8.06%, respectively, P<0.05).They were followed up for 3 years.The re-currence rates, DFS and 3 year survival rate were 45.16%, (16.62 ±4.78) months and 62.90%, respectively;and re-currence rate of patients with ANGPTL 2 and miR-211 protein positively expressed were significantly higher than that of patients with ANGPTL2 and miR-211 protein negatively expressed .DFS of patients with ANGPTL2 and miR-211 pro-tein positively expressed were shorter than that of patients with ANGPTL 2 and miR-211 protein negatively expressed . And 3 year survival rate of patients with ANGPTL 2 and miR-211 protein positively expressed were significantly lower than that of patients with ANGPTL2 and miR-211 protein negatively expressed (P<0.05).Logistic linear regression analysis results showed that , ANGPTL2 and miR -211 protein positive expression rate in gastric cancer tissue could effect the prognosis (P<0.05).Conclusion ANGPTL2 and miR-211 protein positive expression rate in gastric cancer tissue are high and can effect the recurrence rate , 3 year survival rate and DFS and other prognosis condition .Therefore, ANGPTL2 and miR-211 protein expression in gastric cancer tissue may be reference indicator for poor prognosis evaluation .