An prognostic analysis of hypofractionated radiation plus Temozolomide for newly diagnosed glioblastoma in eld-erlies
CHEN Zi-yang
OUYANG Hui
LU Yun-tao
YUAN Ya-wei
YU lei
LIU Ya-wei
QI Song-tao
Abstract：Objective To investigate if a short -course concurrent chemoradiotherapy that yields a better mean survival in elderly patients with newly diagnosed glioblastoma multiforme (GBM) and poor post -operation performance. Methods This study included 71 newly diagnosed primary GBM patients aged 65 years or older with poor post -opera-tion KPS.Kaplan-Meier method stratified by MGMT status was used to compared the survival in different groups .Re-sults The mean age was (71.10 ±5.19) years old, among whom the mean age of 50 males was (71.36 ±5.35)years, and of 21 females was (70.48 ±4.90) years.Sixty-two cases died during follow -up, and the two-year survival rate was 0%.The mean overall survival of short -course concurrent chemoradiotherapy increased significantly ( P=0.002 ) compared to short-course radiotherapy -alone and TMZ-alone ( P=0.001 ) .It got more survival benefit for patients with negative MGMT (P=0.004).But there was no significant difference between short -course radiotherapy -alone and TMZ-alone (P>0.05).Conclusion Short-course concurrent chemotherapy may be a optimization adjuvant therapy plan to elderly patients with newly diagnosed GBM and poor post -operation performance , and this advantage is more obvi-ous in patients with MGMT promotor methylation .
Keywords：elderly patientsadjuvant therapyglioblastomaprognosis
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 24-28 )