The correlation between the natural outcomes of HCV infection and HLA polymorphism among voluntary blood donors
FU Ping-ping
HUANG Jie-ting
SONG Dan-dan
HUANG Ke
XU Ru
LIAO Qiao
SHAN Zhen-gang
LIANG Ming-yue
RONG Xia
FU Yong-shui
WANG Min
Abstract：Objective To evaluate the correlation between the natural outcomes of hepatitis C virus ( HCV) in-fection and HLA polymorphism among Guangzhou blood donors , which could provide scientific data for treatment , preven-tion and vaccine development of HCV .Methods A total of 373 HCV infection blood donors , who donated in Guangzhou blood center , were recruited , including 133 blood donors with spontaneous HCV clearance and 240 with HCV persistent infection.Sequencing-based typing (SBT) methodology was used for detection of genotype HLA class II alleles .The differences in allelic frequencies of HLA -DPB1, DQB1 and DRB1 between spontaneous clearance group and persistent infection group were analyzed using the χ2 test.Multivariate logistic regression analysis was applied to identify independent factors associated with natural outcomes of HCV .Results The participants in spontaneous HCV clearance group were sig-nificantly younger (P=0.003), and with significantly higher female/male ratio (34.6%vs.17.9%, 2=13.090, P<0.01) than those in HCV persistent infection group .HLA-DQB1*05:02 (P=0.002, OR=0.411, 95%CI=0.232-0.727) and DRB1*14:54 (P=0.027, OR=0.350, 95%CI=0.132-0.926) were significantly more frequent in HCV persistent infection group , while the frequency of DRB 1*11:01 was significantly higher in spontaneous HCV clearance group (P=0.007, OR=2.169, 95%CI=1.223-3.848).The following variables were found independently associated with HCV clearance, age (P<0.01, OR=1.035, 95%CI=1.018-1.053), gender (P<0.01, OR=0.423, 95%CI=0.297-0.603), and HLA-DQB1*05:02 (P=0.016, OR=0.480, 95%CI=0.264-0.873), and HLA-DRB1*11:01 (P=0.016, OR=2.072, 95% CI=1.142-3.758).Conclusion Our results show that female and young subjects are more likely to have HCV spontaneous clearance .After HCV infection, subjects who carry DQB1*05:02 are more likely to develop persistent infection , while DRB1*11:01 carriers are in favor of spontaneous clearance .
Keywords：hepatitis C virushuman leukocyte antigenvolunteer blood donorsnatural outcomes
Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 3738-3742 )