Correlation analysis of DNA HBV and tumor markers in patients with hepatitis B cirrhosis.
LI Ya-wei
ZHAO Xiao-jie
MU Li-qin
LI Zhi-juan
DONG Hong
Abstract：Objective To investigate the correlation between HBV DNA and tumor markers in patients with hepa-titis B ( HB) infection and liver cirrhosis , guidance for early diagnosis of liver cancer .Methods Sixty patients with hep-atitis B cirrhosis and 60 cases of liver cancer were selected as cirrhosis group and liver cancer group , respectively .The HBV DNA was detected by PCR method , and AFP-L3 and GP73 were detected using enzyme -linked immunoassay . Results The HBV DNA, AFP-L3 and GP73 expression were significantly lower in liver cirrhosis group than those of liver cancer group (P<0.05).But there was no significant difference in HBV DNA or GP 73 positive expression rate be-tween the 2 groups ( P>0.05 ) .There was significant difference in AFP -L3 positive rate between the 2 groups ( P<0.05).Pearson correlation analysis showed that HBV DNA quantitative and AFP -L3 and GP73 expression had no obvi-ous correlation (rAFP-L3 =0.422, P=0.192; rGP73 =0.349, P=0.228).The sensitivity, specificity and accuracy of HBV DNA, AFP-L3 and GP73, and the joint diagnosis were 86.67%, 20.00%and 53.33%;68.33%, 90.00%and 79.17%;78.33%, 30.00%and 54.17%; and 68.33%, 91.67% and 80.00%, respectively .Conclusion There is no significant correlation between HBV DNA and AFP -L3 or GP73 expression in hepatitis B cirrhosis patients , while AFP-L3 can be used to identify liver cancer and liver cirrhosis , HBV DNA and GP73 cannot distinguish liver cancer and liver cirrhosis caused by hepatitis B infection .
Keywords：hepatitis Bliver cirrhosisliver canceralpha fetoprotein variantGolgi protein
Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 3535-3537 )