An study on the relationship between interleukin -17 and familial aggregation of hepatocellular carcinoma
ZHANG Fen-fen
WU Jian-lin
GONG Ting-ting
HU Die-fei
NING Qiu-yue
PANG Yu
JIANG Li
WU Ji-zhou
Abstract：Objective To investigate the correlation between serum level of cytokine interleukin ( IL)-17 and fa-milial aggregation of hepatocellular carcinoma ( HCC ) .Methods Enzyme-linked immunosorbent assay ( ELISA ) was used to detect serum levels of IL -17 in 112 paired subjects of carcinoma -free members from HCC high-incidence fami-lies (the experimental group) and those from carcinoma-free families (the control group), a total of 224 cases, in areas of high incidence of liver cancer in Guangxi .Results There was significant differences between the two groups in the lev-el of IL-17, independent from sex , age, nation and HBsAg infection .In carcinoma-free members from HCC high -in-cidence families , there was no significant difference in the level of IL -17 among family members with different genetic co-efficient (Z=4.831, P=0.185).The level of IL-17 declined with the increased in the number of HCC patients in HCC high-incidence families (t=0.580, P=0.563).The incidence rate of HCC in men was significantly higher than that in women .Conclusion There is a correlation between the increased expression of IL -17 in carcinoma-free members from HCC high-incidence families and familial clustering of HCC .
Keywords：cytokineIL-17familial aggregationhepatocellular carcinoma
Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 2746-2749 )