between rs7975232 and rs731236 vitamin D receptor Gene polymorphisms and idiopathic hypocitratu-ria in the Yi population of Yunnan
LI Kang-jian
MO Yin
SHEN Ji-hong
LIU Xiao-dong
LUO Yu-hui
LI Hao
Abstract：Objective To investigate the association between rs 7975232 and rs731236 vitamin D receptor gene polymorphisms and idiopathic hypocitraturia in the Yunnan Yi population and its clinical significance .Methods A total of 180 idiopathic hypocitraturia patients and 108 controls with normal urinary citrate from the Yunnan Yi population were enrolled, and he association between rs 7975232 and rs731236 vitamin D receptor gene polymorphisms and idiopathic hy-pocitraturia was analyzed by Sanger sequence detection .Results Between patients and controls , there was significant difference in the genotype frequency of the VDR gene SNP locus rs 7975232 (P<0.05), and the genotype AA was more often in patients.The 24-hour urinary citrate content in genotype AA [(372.92 ±195.03) mg/24 h] was significantly lower than those in genotype CC and CA [(515.47 ±195.02)mg/24 h and (494.85 ±191.95)mg/24 h, respectively, P<0.05].Conclusion Idiopathic hypocitraturia in the Yunnan Yi population has the association with rs 7975232 vita-min D receptor gene polymorphisms , and the genotype AA may be the candidate gene .
Keywords：Yunnan Yi populationvitamin D receptorsingle nucleotide polymorphismidiopathic hypocitratu-riaSanger sequence
Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 2580-2584 )