The effects of Zhengzhifang on reversing atherosclerosis by regulating MMP-9 and TIMP-1
HUANG Zeng-yan
HUANG Man-ping
LIANG Dong-hui
LIU Yong-yuan
JIANG Wei-qiang
ZHANG Wei
Abstract：Objective To investigate the effects of Zhengzhifang on matrix metalloproteinase (MMP-9) and tis-sue inhibitor of metalloproteinase-1 (TIMP-1) in rabbits with atherosclerosis (AS) and its possible mechanism.Meth-ods High fat diet was applied to establish the hyperlipidaemia ( HLP) model.New Zealand rabbits were randomly divid-ed into 4 groups:normal group (n=5), model group (n=8), Zhengzhifang group (n=10), and fluvastatin group (n=8).Blood lipids (including TG, TC, LDL-C and HDL-C) were collected at baseline, 12th and 16th week.MMP-9 and TIMP-1 were assessed with immunohistochemistry.Results Compared with model group, the severity of AS was significantly alleviated in Zhengzhifang group, with significantly lower serum total cholesterol and low-density lipoprotein levels (P<0.05).So was significant increase of high-density lipoprotein, down-regulation of MMP-9 and up-regu-lation of TIMP-1 (P<0.05).Conclusion Zhengzhifang can significantly lower serum LDL-C and CHOL, and in-crease HDL-C.This effect may be related to the inhibition of MMP-9 and enhance of TIMP-1 in vascular wall in AS rabbits.
Keywords：Zhengzhifangatherosclerosismatrix metalloproteinase
Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 2224-2227 )