Expression and significance of Aquaporin 4 and P65 in brain and lung tissues of patients with enterovirus 71 in-fection complicated with neurogenic pulmonary edema
HE Zhen
ZHENG Wei-hua
OU Wei-lin
TANG Fang
YAN Lan
ZHONG Tao
LI Xiong
Abstract：Objective To study the significance of Aquaporin 4 ( AQP4 ) and P65 in the pathogenesis of neuro-genic pulmonary edema ( NPE) through detecting the expressions of AQP 4 and P65 in brain and lung tissues from death cases caused by enterovirus71 (EV71) infection complicated with NPE.Methods Ten cases died of EV71 infection complicatedwith pulmonary edema were selectedas the study group (Group PE), and ten cases died of non -EV71 infec-tion complicated with pulmonary edemain the same period were enrolled as the control group (Group C).The qualitative measurements of AQP4 and P65 inbrain and lung tissue were analyzed by immunohistochemical staining method , and semi-quantitative detection of that was using integraloptical density ( IOD) method.Results Immunohistochemistry results showed that the expression of P 65 and AQP4 in lung tissues were strong positive in the Group PE , and the IOD values were significantly higher than those in Group C (P<0.05).The expression of P65 and AQP4 in brain tissue were positive in the Group PE group, and the IOD values were also significantly higher than those in Group C (P<0.01).Conclusion The AQP4 and P65 are highly expressed in brain and lung tissues of cadavers with EV 71 infection complicated with neurogenic pulmonary edema, suggesting that AQP4 and P65 probably are involved in the pathogenesis of NPE caused by EV 71.
Keywords：enterovirus71neurogenic pulmonary edemaAquaporin 4P65
Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 1957-1960 )