Effect on the platelet aggregation elevation induced by homocysteine on cardiovascular diseases
KONG Fan-li-ang
CHEN Xiao-yan
CHEN Jin
XU Yuan-jie
ZHAO Qiang
WU Tong-guo
Abstract：Objective To investigate the correlation between elevated homocystein ( Hcy) and the platelet aggre-gation, and its influence on cardiovascular diseases .Methods This retrospective study was conducted in 338 patients with hypertension and/or coronary heart disease (CHD).The correlations between Hcy concentration and CHD , stable angina (SA), unstable angina(UA), acute myocardial infarction (AMI), heart failure (HF), the severity of coronary artery lesion, the re-hospitalization rate or platelet aggregation were analyzed .Results The frequencies of CHD , UA, AMI and HF were 84.7%, 44.1%, 33.5% and 41.2%, respectively, in high Hcy group (Hcy≥13 mmol/L) versus 67.3%, 27.4%, 21.4%and 18.5%, respectively, in low Hcy group (Hcy<13 mmol/L, P<0.05).In addition, the frequency of three-vessel lesions were 53.5% and 32.7% in high Hcy group and low Hcy group , respectively ( P=0.001), and the re -hospitalization rateswere 42.4% in high Hcy group and 19.5% in group low Hcy group ( P <0.001).The AA in high Hcy group was significantlyhigher than that in low Hcy group (2.66 ±4.06 vs 1.20 ±2.74, P<0.001).Conclusion As Hcy concentration elevating, the platelet aggregation is rising, which increases the morbidity of CHD and adverse prognosis .
Keywords：homocysteineplatelet aggregationcardiovascular disease
Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 1948-1951 )