Effects of maternal separation on vulnerability to depression and the expression of GluR1 in adult rats
HUANG Ming-fa
XU Ting
WEI Zhi-sheng
LI Xu-ran
ZHENG Yu
ZHOU Qin-ji
DONG Jian-yang
CAI Xiang
Abstract：Objective To investigate the effect of maternal separation on vulnerability to depression and the ex-pression of GluR1 in adult rats .Methods Fifty-six newborn male SD rats were randomly assigned to four groups , con-trol, MS, CRR and MS+CRR groups.The rats in MS and MS+CRR groups received maternal separated for 3 h on Day 2 to Day 14 after birth.The rats in CRR and MS+CRR groups were subjected to three -hour chronic repeated restraint stress ( CRR) for 10 days at 6 weeks old ( weight were sub behavioral changes were recorded by open -field test ( OFT) , novelty suppressed feeding test ( NST) and forced swim test ( FST) .Western blot was used to measure the expression of GluR1 in hippocampus .Results Compared with the control , MS and CRR groups , the total distance of OFT in MS +CRR group was significantly reduced , with significant increases of the latency time of NSF and the immobility time of FST (P<0.05).The expression of GluR1 in hippocampus in MS group was down -regulatedcompared to control group (P<0.05).Compared with the other three groups , significant down-regulation in GluR1 in hippocampuswas revealed in MS+CRR group (P<0.05).Conclusion Maternal separation causes vulnerability to depression in rats at adult age .And the expression of GluR1 in hippocampus is involved .
Keywords：depressionmaternal separationvulnerability to depressionGluR1
Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 1913-1916 )