The influence factors of fracture Healing in High Altitude Area

DU Guo-cong; QIN Jun-liang; AHDuo; LI Qi-zhong; MENG Geng-yao

Abstract：Objective To compare the bone healing time of intertrochanteric fractures between highlands and coastal areas ,so as to investigate influence of special geographical climatein plateau area on fracture healing .Methods Patients with intertrochanteric fracture in plateau region ( Nyingchi area of Tibet autonomous region ,altitude over 3000 me-ters) were enrolled as observation group (n=30),and in coastal areas (City of Zhaoqing, Guangdong province, altitude of 110 meters)were enrolled as control group (n=30).The same treatment was provided toboth groups .The time offrac-ture healing was compared.The clinical data were collected and the influencing factors (including age, gender, fracture type, the degree of osteoporosis , preoperative complications , postoperative weight -bearing activity time, triglyceride, blood viscosity , oxygen points pressure , atmospheric pressure , temperature and humidity ) were analyzed .Results Frac-ture healing time was significantly lengthened in observation group ( P<0.001 ) .Univariate analysis showed that age , fracture type ( Evans type ) , the degree of osteoporosis , weight -bearing activity time , blood viscosity , oxygen partial pressure, atmospheric pressure, temperature, and humidity were the influence factors of fracturehealing (P<0.05).Mo-reover , logistic regression analysis results show that the weight -bearing activity time , oxygen partial pressure , atmospher-ic pressure , and temperature were theprotective factors of fracture healing , while age was the risk factor of fracture heal-ing.Conclusion Compared with patients with fracture in coastal areas , the fracture healing in plateau is affected not only by age and weight -bearing activity time , but also the plateau low oxygen partial pressure , low atmospheric environment , cold and other special geographic and climate factors .