Correlation between circulating tumor cells and clinicopathological characteristics in operable breast cancer pa-tients
LYU Hai-tong
SHI Yu-mei
AN Sheng-li
ZHANG Guo-chun
REN Chong-yang
WEN Ling-zhu
LIAO Ning
Abstract：Objective To investigate the correlation between circulating tumor cells ( CTCs) CTCs and clinico-pathological characteristics in operable breast cancer patients .Methods From January 2009 to January 2016, 126 oper-able breast cancer patients in Guangdong General Hospital were enrolled in this study .Samples of peripheral blood (7.5 mL) were collected for detection of CTCs using the CellSearch System .The correlation between CTCs and clinicopathologi-cal characteristics in operable breast cancer patients was analyzed .Results The CTCpositive rate in patients with operable breast cancer was 7.1%(9/126).Ki67 in CTCs positive and negative group were 51 ±20%and 33 ±23%, respective-ly, with statistically significant difference (P=0.04).The CTCpositive rates in operable breast cancer patients showed no significant difference among the different subgroups with regards to menopausal status , tumor size, lymph node stage, AJCC stage, histological grade, histological type, hormone receptor(ER) status,progestogen receptor (PR), status hu-man epithelial growth factor receptor 2 (HER2) expression,or molecular types.Conclusion CTCs aredetected in 7.1%operable breast cancer patients .Ki67 is the sole primary tumor characteristic that correlates with the presence of CTCs in operable breast cancer patients .Long-term follow-up will be required to investigate the relationship between CTCs and prognosis in operable breast cancer .
Keywords：breast tumorcirculating tumor cellsCellSearch system
Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 1819-1822 )