Expression of pituitary tumor transforming gene and basic fibroblast growth factor and its relationship with clini-cal pathological characteristics of bile duct carcinoma
YU Jian-xiong
CHEN Guo-rong
Abstract：Objective To investigate human pituitary tumor transforming gene ( PTTG ) and basic fibroblast growth factor ( b-FGF) expression in cholangiocarcinoma and their correlation , as well as relevant clinicopathological pa-rameters, for diagnosis and early treatment of cholangiocarcinoma .Methods 58 cases of cholangiocarcinoma tissue were collected as the observation group , and 20 cases of normal bile duct tissue from patients with gallstones were collected as the control group .The expression of PTTG and b -FGF in the two groups was detected by immunohistochemistry , and the results were studied and analyzed .Results The positive rate of PTTG and b -FGF was 81.03%and 74.14%, respec-tively.Positive expression rates in cholangiocarcinoma , were significantly higher than in the control group ( P<0.05). PTTG expression in cholangiocarcinoma was positively correlated with the expression of b -FGF.Conclusion High ex-pression of PTTG in cholangiocarcinoma induces extracellular secretion and high expression of b -FGF.Meanwhile, B-FGF also induces the expression of PTTG .High expression of PTTG and b-FGF is closely related to the biological behav-iors of cholangiocarcinoma .Expressions of PTTG and b -FGF in cholangiocarcinoma are positively correlated .Combined detection of PTTG and b -FGF can help determine the degree of malignancy , guide treatment and predict prognosis of cholangiocarcinoma .
Keywords：cholangiocarcinomapituitary tumor transforming genebasic fibroblast growth factorimmunohisto-chemistr
Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 678-681 )