Efficacy of Jianpi Liqi Yiliu Formula combined with CIK treatment on the immune function and quality of life in patients with advanced hepatocellular carcinoma
ZHANG Xiao-xuan
LONG Shun-qin
YANG Xiao-bing
ZHOU Yu-shu
HE Wen-feng
LIAO Gui-ya
OU YANG Yu-shu
LI Qiu-ping
HUANG Jin-peng
DENG Hong
PAN Zong-qi
WU Wan-yin
Abstract：Objective To observe the efficacy of Jianpi Liqi Yiliu Formula ( JLYF) combined with cytokine-in-duced killer ( CIK) cells on the immune function and quality of life in patients with advanced hepatocellular carcinoma ( HCC) .Methods Sixty patients were randomly assigned to receive either JLYF and CIK treatment ( the treatment group) or dialectical decoction and CIK treatment (the control group).The immune function and quality of life (QOL) were evaluated by T lymphocyte subset assay and EORTC QLQ-C30 score.Results The T lymphocyte subset assay showed that the percentages of CD3 +, CD4 +, CD8 +and NK+were increased after treatment in the treatment group, as well as in the control group.There was a statistically significant difference in the CD3 +difference before and after treat-ment between two groups ( P<0.05 ) .The scores of physical function, emotional function and general health were in-creased and the scores of fatigue, nausea, short of breath, appetite, constipation, diarrhea were decreased after treatment in the treatment group (P<0.05).The score of physical function was increased and score of fatigue was decreased after treatment in the control group (P<0.05).With regards to scores of general health and fatigue, there was a statistically significant difference in the difference before and after treatment between two groups ( P <0.05 ) .No severe adverse events were observed.Conclusion Both treatment strategies can enhance the immune function and QOL, while JLYF combined with CIK treatment is more effective than dialectical decoction combined with CIK treatment.
Keywords：Jianpi Liqi Yiliu Formulacytokine-induced killer cell treatmentadvanced hepatocellular carcino-maimmune functionquality of life
Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 441-444 )