Correlation between MHC gene frequency distribution and sMⅠCA expression in thyroid carcinoma
SHEN Li-ang
HUANG Ying-feng
LIANG Liu-sen
ZENG Xiu-yi
ZHANG Shuai
Abstract：Objective To investigate the MHC gene frequency distribution and sMⅠCA expression levels in thy-roid carcinoma, as well as their correlation.Methods Forty-four patients with thyroid carcinoma, 87 with benign thy-roid nodules and 133 healthy individuals were enrolled and whole blood sample was collected for each subject.The MHC (HLA, MⅠCA and MⅠCB) alleles were identified by SBT.Gene frequency was analyzed by PyPopWin32 software. SPSS20.0 was used to analyze the correlation of cancer with MⅠCA/B and HLA allelic frequency.ELISA was applied to semi-quantitatively measure the serum concentration of soluble MⅠCA (sMⅠCA).Results (1)MⅠCB*004:01 was a protective factor from thyroid carcinoma [P=0.014, RR(95%CI)=0.122(0.016~0.91)];(2)DRB1*15:01 and DRB1*04:03 were protective alleles of benign thyroid nodules (P<0.05, RR<1); (3)There was no significant difference among patients with thyroid carcinoma, benign thyroid nodules and healthy individuals in the level of sMⅠCA. The mean sMⅠCA level of thyroid carcinoma patients is(0.233 1 ±0.244 5)ng/mL.Conclusion MHC system is associ-ated with thyroid carcinoma, of which MⅠCB*004:01 is correlated with risks of thyroid carcinoma.
Keywords：thyroid carcinomaMHCallelesMⅠCA
Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 361-365 )