Expression of miRNA-32,-196a,-218,-128 and let7i in serum of patients with prostate cancer and its clinical significance
FENG Qiang
HUANG Xiang
Abstract：Objective To investigate the expression of miRNA-32, miRNA-196a, let7i and miRNA-218, miRNA-128 in serum of patients with prostate cancer.Methods The relative expression level of miRNAs was detected by real-time fluorescence quantitative PCR in serum of patients with prostate cancer.Correlation between marker expres-sion and the clinical pathological parameters of prostate cancer was analyzed.Results High expression of miRNA-32,-196a, and -128 was detected in prostate cancer, while let7i and miRNA-218 showed low expression in prostate canc-er.The level of miRNA-32 in serum of patients with prostate cancer was significantly higher than that in the normal group.Significantly different levels of expression were found in the comparison between pathological staging of T1~2 and T3~4 , between Gleason score less than or equal to 7 and more than 7 and between whether lymph node metastasis was pres-ent(P<0.05).Conclusion miRNA-32 as a diagnosis marker of prostate cancer has a high efficiency.
Keywords：prostate cancermiRNAserumreal-time PCR
Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 73-76 )