Correlation of gene polymorphism loci+2438C/G?rs?1058587 of growth differentiation factor 15 with acute myo-cardial infarction
LUO Dong-lei
LI Yong-jun
GUO Jing-tao
ZHOU Jiang
ZHAO Zhi-guo
LIU Tong
ZOU Xue-song
LIU Bing-hui
Abstract：Objective To investigate the correlation of growth differentiation factor 15 ( GDF-15) gene polymor-phism loci +2438C/G?rs?1058587 with acute myocardial infarction .Methods An acute myocardial infarction ( AMI) group (n=20) and a non-coronary-heart-disease (NCHD) group (n=72) were chosen.Serum levels of biochemical markers and GDF-15 were measured .Gene polymorphic analysis was performed on GDF -15 gene polymorphism loci +2438C/G?rs?1058587.Results Polymorphism typing of GDF -15 gene polymorphism loci +2438C/G?rs?1058587 of the AMI group and the NCHD group revealed no statistically significant difference (X2 =0.246, P=0.970).The clinical characteristics and serum levels of biochemical markers were similar among different genotypes (P>0.05).Conclusions Gene polymorphism loci+2438C/G?rs?1058587 of GDF-15 is not correlated with acute myocardial infarction .GDF-15 gene polymorphisms at loci +2438C/G?rs?1058587 may not affect levels of GLU , UA, CR, TC, TG, HDL-C, LDL-C, hsCRP, GDF-15.
Keywords：acute myocardial infarctiongrowth differentiation factor -15gene polymorphismgene polymor-phism loci
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 3470-3472,3473 )