Establishment of an animal model of endometriosis in macaca fascicularis
ZHU Feng-cheng
LIU Mu-biao
PAN Ying
WANG Xue-feng
CHEN Yan-ying
Abstract：Objective To establish an animal model of endometriosis in macaca fascicularis .Methods Fifteen female macaca fascicularises were selected .Surgery was performed in the experimental group to collect endometrial tis-sues, which were then implanted into the pelvic omentum majus , douglas pouch , as well as uterus surface .A similar sur-gery was operated on the control group , in which the omentum majus was collected and implanted instead .Laparoscopic exploration was performed eight weeks and sixteen weeks postoperatively , followed by histopathological examination of sus-pected lesions .Results In the experimental group , eight female macaca fascicularis models of endometriosis were suc-cessfully established .Histopathological examination of suspected lesions revealed complete structure of the glands and stro -mal cells.Model establishment failed in the 5 subjects of the control group .Conclusion The endometriosis model of macaca fascicularis was successfully established , which adds a new animal choice to the research of endometriosis .
Keywords：endometriosismacaca fascicularisanimal model
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 3421-3424 )