Clinical characteristics and adaptive servo-ventilation treatment outcomes of complex sleep apnea syndrome.

XIAO Bing; HE Zhi-wei; LI Hao-bo; LIU Yuan-yuan; QIAN Xiao-sen; LIU Yi

Abstract：Objective To observe the characteristics of complex sleep apnea syndrome ( CompSAS) and to evalu-ate the therapeutic outcomes of adaptive servo-ventilation ( ASV) on patients with CompSAS.Methods 303 adult pa-tients underwent continuous positive airway pressure ( CPAP) titration for moderate-severe obstructive sleep apnea-hy-popnea syndrome ( OSAHS) were prospectively studied.Patients were divided into simple OSAHS group and CompSAS group.The CompSAS group was then treated with ASV.Age, gender, weight, BMI, comorbidities were all recorded as well as sleep efficiency, sleep structure, events, lowest oxygen saturation ( LSaO2 ) by polysomnograph ( PSG) for the first night and during CPAP titration and ASV therapy, respectively.Results Nineteen (6.2%) out of the 303 patients under CPAP treatment met the criteria of CompSAS. Prevalence of hypertension ( 73.6%) and congestive heart failure (26.3%) in patients with CompSAS were higher compared to simple OSAHS patients (42.9% and 7%, P<0.05). Central apnea index (CAI) in CompSAS group was increased by CPAP treatment [(9.50 ±2.94)/h] compared to that before CPAP titration [(2.95 ±2.88)/h] (P<0.05).Sleep efficiency, stage Ⅲ sleep proportion and LSaO2 were in-creased with ASV therapy in patients with CompSAS, while AHI and CAI were decreased compared to that with CPAP ti-tration.Conclusion CompSAS patients had higher prevalence of hypertension and congestive heart failure and higher MAI on PSG.Compared with CPAP, ASV therapy may better improve sleep quality, reduce AHI and CAI, and control hypoxemia for patients with CompSAS.