Effects of self-monitoring of blood glucose on antidiabetic treatment in non-insulin-treated type 2 diabetes mellitus patients with depression or anxiety

OUYANG Hai-chun; MAI Si-zi; WU Wo-dong; HU Yun-zhao; WU Yan-xian; LI Wen-sheng; CHENG Yu-ying

Abstract：Objective To study the effects of self-monitoring of blood glucose (SMBG) on antidiabetic treat-ment in non-insulin treated type 2 diabetes mellitus patients with depression or anxiety and evaluate whether SMBG is ap-plicable in type 2 diabetes mellitus patients with depression or anxiety.Methods A total of 796 cases of non-insulin treated type 2 diabetes mellitus patients from the same community medical center were enrolled.All subjects completed surveys with self-rating depression scale (SDS) and self-rating anxiety scale (SAS) .Patients were classified as mild depression,moderate to severe depression,and/or mild depression,moderate to severe anxiety,or no emotional disorder (ED) based on SDS and SAS scores.According to blood glucose monitoring methods,patients within each emotional sta-tus were randomly divided into SMBG group and venous plasma glucose monitoring (VPG) group.Patients were followed up for 16 weeks.The following outcomes were compared,frequency of self-adjustment of blood glucose measurement,percentage of patients with self-adjustment of antidiabetic drugs and percentage of patients reaching clinical HbA1c tar-get.Results In the moderate to severe depression or anxiety patients of the SMBG group,frequency of self-adjustment of blood glucose measurement and percentage of patients with self -adjustment of antidiabetic drugs were significantly higher than in the VPG group (P<0.05) .At the end of the investigation,the percentage of patients reaching clinical HbA1c target in the SMBG group was lower than in the VPG group (P<0.05).Conclusion SMBG is not applicable in non-insulin treated type 2 diabetes mellitus patients with moderate to severe depression or anxiety.These patients may al-ter blood glucose monitoring and antidiabetic treatment regimen without medical consults due to emotional factors of depres-sion or anxiety,which plays a negative role in reaching target blood glucose.