Expression and clinical significance of p-PI3K/p-AKT protein in neuroblastoma
WANG Juan
GUO Xiao-fang
SUN Xiao-fei
ZHEN Zi-jun
ZHU Jia
LU Su-ying
SUN Fei-fei
CHEN Yan
ZHANG Fei
CAI Rui-qing
LI Mei
Abstract：Objective To investigate the expression of the p-PI3K/p-AKT protein and its correlations with clinical manifestations and prognosis in neuroblastoma (NB).Methods The clinical information and paraffin block of the tumor specimens of newly diagnosed,untreated patients with NB were collected.The expression of p-PI3K/p-AKT in tumors was detected by immunohistochemistry,and its effect on survival of NB patients was analyzed.Results A total of 65 patients with NB were enrolled,with a median age of 3 years and a median follow-up time of 38.6 months.The ex-pression rates of p-PI3K and p-AKT in NB patients were 70.7% (46/65) and 70.7% (41/65),respectively.And the high expression rates were 63.1%(41/65) and 66.2%(43/65),respectively.The expression level of the p-PI3K in NB was positively correlated with that of p-AKT (P=0.021).But the expression level of p-PI3K and p-AKT didn′t affect the overall survival and didn′t correlate with the clinical characteristics of the NB patients.Conclusion The PI3K/AKT signal pathway was extensively expressed in patients with NB,which may reveal a promising therapeutic target for NB patients.
Keywords：neuroblastomaPI3KAKT
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 2629-2634 )