Correlation between GRACE score and cardiovascular risk factors in patients with acute coronary syndrome

MA Bing-ning; XU Ge

Abstract：Objective To investigate the correlation between the global registry of acute coronary event ( GRACE) score and cardiovascular risk factors in patients with acute coronary syndrome ( ACS) .Methods A total of 692 patients who met the diagnostic criteria of ACS were selected divided into 3 treatment groups, 220 cases in the low risk group, 240 cases in the intermediate risk group, 232 cases in the high risk group.Correlation between the GRACE score and cardiovascular risk factors was analyzed by both univariate and multivariate binary logistic regression.Results Uni-variate logistic regression demonstrated that higher ACS risk was correlated with higher GRACE score, larger proportion of patients having one of the cardiovascular risk factors, e.g.old age, hypertension, male and smoking, elevated levels of cysC, Fib, Hcy, ApoB and ApoB/ApoA, and lower ApoA level.Multivariate logistic regression showed that Fib, ApoB/ApoA, Hcy, CysC, old age, male and hypertension were independent risk factors which aggravate the risk of ACS.Among them, Fib (B=2.091, P<0.001) and old age (B=2.091, P<0.001) were two most prominent risk factors for ACS. Conclusion ACS risk was related to various risk factors, among which Fib and old age were two most prominent inde-pendent risk factors for ACS.Combined application of these indices in ACS patients may have important clinical value in early risk stratification, evaluation of prognosis and decision of treatment options.