Clinical observation of intensity-modulated conformal radiotherapy with concurrent chemotherapy and endogen-ic field hyperthermia for locally recurrent or advanced rectal cancer
MO Kai-lan
CHEN Si-ze
ZHONG Yu-ping
WANG Xi-cheng
Ding Ying
SHANG Yi
Abstract：Objective This study aims to determine the short-term efficacy and safety of intensity-modulated conformal radiotherapy with concurrent chemotherapy and endogenic field hyperthermia for locally recurrent or advanced rectal cancer.Methods Sixty patients with locally recurrent or advanced rectal cancer were randomly divided into two groups, the radiochemotherapy with hyperthermia group ( Group A with 30 patients ) and the radiochemotherapy group ( Group B with 30 patients) .Patients in the two groups received chemoradiotherapy of the same regimen, while patients in Group A underwent additional treatment of endogenic field hyperthermia ( Tumor Endogenic Field Hyperthermia System, Model NRL-004) within 1h after radiotherapy.Efficacy and safety outcomes were evaluated 3 months after the end of all treatments.Further follow -up was implemented for long -term efficacy.Results The effective rate of Group A (90.0%) was higher than that of Group B (66.7%) (χ2 =4.812, P<0.05).Disease control rate was 100% in both groups.There was no significant difference in KPS score, rate of local pain relief or frequency of adverse reactions ( P>0.05).Conclusion Intensity modulated conformal radiotherapy with concurrent CapeOX chemotherapy and endogenic field hyperthermia for locally recurrent or advanced rectal cancer improves short-term efficacy and quality of life while the adverse reaction remained mild.Further study is advisable.
Keywords：intensity-modulated conformal radiotherapyconcurrent chemotherapyendogenic field hyperther-mialocally recurrent rectal cancerlocally advanced rectal cancer
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 2467-2470 )