The correlation between circulating soluble lectin-like oxidized low-density lipoprotein respector-1 and the vascular dysfunction in patients with metabolic syndrome
LI Ai-qun
LUO Cheng-feng
LI Guo-qiang
OU Wen-chao
TIAN Chao-wei
ZHONG-Yun
LIU-Bin
WU Xiao-man
Abstract：Objective To study correlation between circulating soluble lectin-like oxidized low-density lipo-protein respector-1 (sLOX-1) and the vascular dysfunction in patients with metabolic syndrome (MS).Methods Fifty-six subjects were randomly selected from community residents according to diagnostic and exclusion criteria, among whom 27 patients with MS (MS group) and 29 as controls (control group).The carotid pulse wave conduction velocity ( CFPWV) was measured with arterial stiffness measuring instrument, while sLOX-1 was assessed with ELISA kits.Re-sults The sLOX-1 in MS group was significantly higher than control group (P<0.05).The sLOX-1 was also signifi-cantly positively correlated with CFPWV and body mass index (BMI) (CFPWV:r=0.272, P<0.05;BMI:r=0.545, P<0.01), and negatively correlated with high-density lipoprotein (r=0.35, P<0.01).According to linear stepwise regression analysis, age, blood sugar and sLOX-1 had a significant effect on CFPWV.Conclusion SLOX-1 is closely related to vascular function in patients with MS.
Keywords：metabolic syndromesoluble lectin-like oxidized low-density lipoprotein receptor -1carotid pulse wave conduction velocity
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 2007-2009,2010 )