The effect of PON-1 gene polymorphism on the prognosis in the patients with acute organic phosphorus poison-ing
ZHOU Ning
YAO Wei-xue
LI Zhi-wen
LIANG Jin-ming
CHEN Yue-ming
SU Geng
Abstract：Objective To investigate the effect of paraoxonase 1 ( PON-1) gene polymorphism on the prognosis in patients with acute organic phosphorus poisoning .Methods A total of 140 cases of acute organic phosphorus poison-ing treated were study and divided into 3 groups according to gene polymorphism of PON -1 using PCR.The serum cho-linesterase activity , paraoxonase activity , respiratory failure rate and hospital stay were compared .Results In the pa-tients with acute organic phosphorus poisoning , the incidence of respiratory failure was significantly higher in patients with Q/Q genotype than those of Q/R and R/R types;with significantly lower activity of PON -1 and serum cholinesterase and longer hospital stay (P<0.05).Conclusion The PON-1 gene polymorphism affects the condition of patients with acute organic phosphorus poisoning by influencing the activity of PON -1, thus affecting toxic degradation .The gene polymor-phism detection of PON-1 and the activity of PON-1 can be used to judge the severity and prognosis of patients .
Keywords：organic phosphorus pesticidepoisoningparaoxonasegene polymorphism
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 1673-1675 )