The correlation between apolipoprotein gene polymorphisms and steroid - induced osteonecrosis of the femoral head
WEI Xiang-dong
LIANG Jing-chao
ZENG Ping
QIN Gang
LV Liang-qing
Abstract：Objective To study the correlation between apolipoprotein(Apo)A1,ApoB and ApoE gene poly-morphisms and the susceptibility to the steroid - induced osteonecrosis of the femoral head(SONFH). Methods Forty -five patients with SONFH were enrolled as SONFH group and 30 patients who accepted adrenal cortical hormone for treat-ment in 6 months without SONFH were enrolled as control group. DNA from the blood sample were extracted,and SNaP-shot genotyping analysis and DNA direct sequencing were used to analyze single - nucleotide polymorphisms of ApoA1 (rs1799837),ApoB(rs693),ApoB(rs1042031),ApoE(rs7412)and ApoE(rs429358). Results The frequencies of AG genotype and A allele frequencies in ApoA1(rs1799837),and the frequencies of AG genotype and A allele in ApoB(rs1042031)in SONFH group were significantly higher than those in control group(P < 0. 05). The remaining sites gene polymorphism showed no significantly difference between the two groups(P > 0. 05). In ApoA1(rs1799837) and ApoB(rs1042031),compared to AG genotype,the risk of SONFH of GG genotype was significantly reduced(P <0. 05);compared with A allele,the risk of SONFH of G allele was significantly reduced(P < 0. 05). Conclusion The gene polymorphism of ApoA1(rs1799837)and ApoB(rs1042031)may be related to the susceptibility of SONFH.
Keywords：steroid induced osteonecrosis of the femoral headapolipoproteingene polymorphism
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 1364-1368 )