Applications of fatal ductus venosus pulsatility index of vein and hepatic artery pulsatility index in Down syn-drome screening for pregnant women at 11-13 +6 weeks
LUO Qing
WAN Jun-hui
DAI Chang-ping
XIAO Qing-hua
JIANG Jin-xiong
CAO Xiao-zhen
Abstract：Objective To evaluate the applications of fatal ductus venosus pulsatility index of vein ( DV-PIV) and hepatic artery pulsatility index ( HA-PI) in Down syndrome screening for pregnant women at 11 -13 +6 weeks. Methods 223 women with singleton pregnancy with high risk for aneuploidy in combined screening test and normal nu-chal translucency ( NT) measurements were included as study group, and 252 women with similar age, gestational age, normal NT measurements and low-risk in first trimester combined tests were enrolled as control group.Fatal DV-PIV and HA-PI were compared between the two groups, while DV-PIV and HA-PI were compared between fetuses with Down syndrome in study group and fetuses in control group.Receiver operating characteristics ( ROC) curves were used to evaluate the capacities of fatal DV-PIV and HA-PI in the diagnosis of trisomy 21.Results Fatal DV-PIV was signif-icantly higher in study group ( P<0.05 ) , whereas no significant difference was revealed in fatal HA-PI ( P>0.05 ) . DV-PIV was significantly higher but HA-PI was significantly lower of fetuses with Down syndrome in study group when comparing with fetuses in control group (P<0.05).The sensitivity and specificity of DV-PIV in the diagnosis of trisomy 21, with the cutoff of 2.1, were 86.1%and 96.2%, respectively.The sensitivity and specificity of HA-PI in the diagno-sis of trisomy 21, with the cutoff of 1.0, were 70.9%and 94.1%, respectively.Conclusion The addition of DV-PIV and HA-PI measurements during the first trimester of pregnancy increases the accuracy for Down syndrome detection.
Keywords：first trimesterDown syndrome screeningductus venosus pulsatility index of veinhepatic artery pulsatility index
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 1182-1185 )