The inhibitory effect of cromoglicate sodium on mast cells in rats with lung arterial hypertrophy
ZHANG Hui
CHEN Liang-wan
Abstract：Objective To investigate the inhibitory effects of cromoglicate sodium on the mast cells in rats with lung arterial hypertrophy, and to investigate the correlation between the function of mast cells and pulmonary vascular re-modeling.Methods The constriction operation on the openings above coronary aorta ( supracoronary aortic banding) was performed on male adult SD rats to establish the PH-LHD rat models.Cromoglicate sodium was given to the treatment group, while replaced saline was given to the rats in model group and sham operation group.Pulmonary vascular remode-ling, and mast cell aggregation and degranulation were observed, while peripheral MCP-1 and IL-6 were assessed using ELISA.Results Mast cell accumulation around pulmonary arterioles was observed on the 36th day, which was alleviated by cromoglicate sodium treatment.The peripheral MCP-1 and IL-6 were significantly elevated in model group when comparing with those in the other 2 groups, which was significantly reduced by cromoglicate sodium treatment ( P <0.05 ) .Conclusion Mast cell accumulation and degranulation around pulmonary arterioles with diameter between 20 and 50 μm plays important role in the pathogenesis of pulmonary hypertension.Membrane stabilizer, cromoglicate sodium, can reduce the inflammatory factors, including MCP-1 and IL-6, thus to inhibit the function of mast cells.
Keywords：mast cellsgatherto take off the particlespulmonary arterial hypertensioninflammatory cytokinescolor nucleoside acid sodium
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 1154-1156 )