Radiosensitizing effects of insulin like growth factor-1 receptor inhibitor on the transplanted tumor of nasopha-ryngeal carcinoma in nude mice
WU Fang-cai
LU Han-gui
Abstract：Objective To study the radiosensitizing effects of AG1024, the insulin like growth factor-1 receptor (IGF-1R) inhibitor, on the transplanted tumor of nasopharyngeal carcinoma (NPC) in nude mice.Methods The transplanted tumor models of human CNE2 NPC in nude mice were established and randomly divided into four groups, the control, the AG1024, the radiation and the combination therapy groups.The latter three groups were treated with AG1024, radiotherapy, AG1024 combined with radiotherapy, respectively.The growth of transplanted tumor was recor-ded.The apoptosis were examined by flow cytometry.The mRNA expression of PCNA and survivin in tumor samples was assessed by RT-PCR.Results Significant inhibitive effect was observed in combination therapy group, with significantly higher apoptosis rate when comparing with the other 3 groups (P<0.05).Expression levels of PCNA and survivin in the combination therapy group were significantly lower than those in the other 3 groups(P<0.05).Conclusion The combi-nation therapy has obviously higher curative efficacy than simple therapy, providing theoretic and clinical basis for the re-search of combination of targeting treating and radiotherapy.
Keywords：insulin like growth factor-1 receptornasopharyngeal carcinomaradiosensitivity
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 985-988 )