The correlation between TLR4 gene promoter 1837A/G polymorphism and primary ANCA associated vasculitis in ;Han population in Guangxi
WU Chun-xiang
XUE Chao
LIAO Yun-hua
LI Wei
CAO Bai-chan
PENG Qian
WEI Xiao-li
GONG Ai-mei
Abstract：Objective To investigate the correlation between TLR 4 gene promoter region -1837A/G polymor-phism and primary ANCA associated small vasculitis ( AAV) in Guangxi Han nationality .Methods TLR4-1837A/G polymorphism was analyzed by polymerase chain restricted fragments length polymorphism in 110 cases with AAV and 101 controls .Clinical and pathologic data of the patients with different genotype were also compared .Results The frequencies distribution of TLR4-1837A/G genotype AA, AG and GG in 110 AAV patients were 53.64%, 40.00% and 6.36%, respectively;and the frequencies of allele A and G were 73.64% and 26.36%, respectively .In controls , the genotype frequencies of AA , AG and GG were 50.50%, 39.60% and 9.90%, respectively; with frequencies of allele A and G were 70.30%and 29.70%, respectively .No significant difference was found in either genotype distribution or allele fre-quencies between the patients and the controls (P>0.05).Significant reductions in the incidence of hematuria , serum C reactive protein , and erythrocyte sedimentation rate was found in AG genotype than those in the other two genotypes ; so was the increase of hemoglobin in AG genotype (P<0.05).Conclusion In the Han nationality in Guangxi , the poly-morphism of TLR4-1837 A/G may be associated with hematuria , hemoglobin , C reactive protein , and erythrocyte sedi-mentation rate in patients with AAV , but not the genetic susceptibility to AAV .
Keywords：ANCA associated small vasculitisTLR4single nucleotide polymorphismgene
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 528-531 )