The effects of cisplatin-implants on the tumor growth and the expression of SYK and HER2 of human gastric ;transplantable tumor on nude mice
YAN Li-ping
CAI Ting-ting
SHI Xiao-ping
LI Hong
LIANG Yong
SHEN Mei-rong
ZHANG Min
Abstract：Objective To observe the effects of sustained -release cisplatin implantation on tumor cell apoptosis and the SYK and HER2 protein expression in nude mouse with subcutaneous gastric carcinoma transplantation . Methods The subcutaneous gastric carcinoma transplantation model with SGC 7901 cell was constructed using BALB/c nude mice, which were further randomly divided into 4 groups:control group (received tail intravenous injection of PBS , Group A), Group B (received tail intravenous injection of cisplatin ), Group C (received intratumor injection of cispla-tin), and Group D (received the implant of cisplatin -implants).After the drugs intervening, the tumors were harvested for assessment of the tumor weight and tumor inhibiting rate , HE staining observation , examination of SYK and HER 2 expression , and assessment of cell apoptosis .Results Sustained-release cisplatin significantly promoted the apoptosis as well as suppressed the tumor growth , with significantly up -regulated the expression of SYK and down -regulated the expression of HER2.Conclusion Cisplatin-implants promotes the tumor apoptosis by enhancing the expression of SYK and reducing the expression of HER 2.
Keywords：cisplatin-implantsgastric cancernude miceapoptosisSYKHER2
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 505-508 )