Adiponectin is associated with severity of ventricular dysfunction in atrial fibrillation patients with congestive heart failure
LI Jie-qi
PENG Hong
YANG Hong-ping
ZHANG Rong-xian
LI Ping
ZHOU Kai-bi
ZHAO Quan-min
LEI Tian-qiong
Abstract：Objective To evaluate of the value of plasma adiponectin ( APN) in diagnosing heart failure in pa-tients with atrial fibrillation.Methods A total of 144 patients with atrial fibrillation were divided into 4 group, NYHA class Ⅰ group, Ⅱ group, Ⅲ group and Ⅳ group.LVEDD, LAD and LVEF were detected by transesophageal echocardio -graphy.Plasma APN level were measured by enzyme -linked immunosorbent assay (ELISA).Results The plasma APN level, NT -proBNP, LVEDD and LAD in atrial fibrillation patients with NYHA class Ⅱ group, Ⅲ group and Ⅳ group were significantly higher than those in NYHA class Ⅰ group (P <0.05), and the differences were gradually increased with the increase of NYHA grading; and the LVEF was significantly per contra (P <0.05).According to correlation anal-ysis, NT -proBNP was significantly correlated with LAD (r =0.33, P =0.036), LVEDD (r =0.512, P =0.006) and LVEF (r =-0.41, P =0.001); and plasma APN was significantly positively correlated with NT -proBNP (r =0.49,P=0.000 2) and LVEDD (r =0.39, P =0.001), while negatively correlated with LVEF (r =-0.55, P =0.001).How-ever, no significant correlation was revealed between APN and LAD (r =0.12, P >0.05).Conclusion Plasma APN, NT -proBNP, LVEDD, LAD and LVEF are gradually changed as the progression of cardiac function in atrial fibrillation patients with heart failure, suggesting the increase of APN is correlated with the myocardial remodeling and prognosis .
Keywords：adiponectinatrial fibrillationNT -proBNPheart failuretransesophageal echocardiography
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 379-381 )