Association between cystathionine βsynthase gene T833C polymorphism and essential hypertension in Kazakh and Uyghur nationalities in Xinjiang

ZHANG Lei; CAI Wei-juan; ZHANG Li-cui; ZHANG Hong-mei; CHENG Jiang

Abstract：Objective To investigate the associations between the plasm homocysteine ( Hcy) levels or cystathi-onine βsynthase ( CBS) T833C gene polymorphism and essential hypertension in Xinjiang Kazakh and Uyghur nationali -ties.Methods Three-hundred Uyghur patients with hypertension ( Uyghur hypertension group ) , 300 Uyghur people with normotension ( Uyghur control group ) , 300 Kazakh patients with hypertension ( Kazakh hypertension group ) , and 300 Kazakh people with normotension ( Kazakh control group ) were enrolled for the study .The Hcy level and related bio-chemical indices in 4 groups were detected with automatic biochemical analyzer .CBS T833C gene polymorphism was de-tected by amplification refractory mutation system (ARMS), and then the associations between the plasma Hcy level or CBS T833C gene polymorphism with essential hypertension was analyzed .Results The plasma Hcy level in Uyghur hy-pertension group and Kazakh hypertension group was higher than Uyghur control group and Kazakh control group with sig -nificant difference (P<0.05).The total frequency distributions and allele frequency distributions of three genotypes be -tween Uyghur hypertension group and Uyghur control group were significantly different ( P<0.05 ) .The total frequency distributions and allele frequency distributions of two genotypes between Kazakh hypertension group and Kazakh control group were significantly different (P<0.05).Conclusion The increase of Hcy level is associated with Kazakh essential hypertension in Kazakh and Uyghur populations in Xinjiang .CBS T833C gene polymorphism has association with essential hypertension in Kazakh and Uyghur populations in Xinjiang .