The effects of cordyceps sinensis on the expression of epidermal growth factor and transforming growth factor-β1 in renal interstitial of patients with obstructive nephropathy
ZHANG Hui-li
XU Mi-qing
XIAO Jie
Abstract：Objective To research the effects and possible mechanisms of cordyceps sinensis in renal interstitial fibrosis in obstructive nephropathy .Methods Rats were randomly divided into 3 groups: sham operation group ( SOR group), unilateral urethral obstruction group (UUO group), and cordyceps sinensis treatment group (CST group).On Day 7, 14, 21, 28 after the operation, blood were collected for evaluation of blood urea nitrogen and serum creatinine . Kidney tissue was processed by HE staining .ELISA was used to detect the epidermal growth factor ( EGF ) level and Western blot method was used to detect the expression of transforming growth factor -β1 ( TGF-β1 ) in kidney tissues . Results There was no significant difference in blood urea nitrogen or serum creatinine among the 3 groups at each time point (P>0.05).The kidney tissue of HE staining in CST group showed renal interstitial fibrosis mitigated when compare with UUO group.The expression of TGF-β1 in renal tissue of CST group was significantly lower than UUO group ( P<0.05), while the expression of EGF was significantly higher (P<0.05).Conclusion Cordyceps may regulate the ex-pression of TGF-β1 and EGF, reduce the renal interstitial fibrosis caused by ureteral obstruction .
Keywords：cordyceps sinensisobstructive nephropathyrenal interstitial fibrosisepidermal growth factortransforming growth factor -β1
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 174-177 )