A diffusion tensor imaging study on patients with major depressive disorder
HU Xue-yu
NING Bu
JIA Fu-jun
YANG Cheng-jia
GUO Mou-ying
GUO Yue-ping
ZHANG Shui-xing
XU Ming-zhi
Abstract：Objective The application of diffusion tensor imaging (DTI) was used to explore the white matter in -tegrity in patients with major depressive disorder (MDD).Methods Brain MR imaging using T1, T2 and DTI se-quences was performed in 38 subjects (21 depressed patients and 17 controls).Voxelwise statistical analysis of FA data was performed using voxel -based analysis (VBA).Results In patients with MDD, significant reduction in FA, an un-specific measure of microstructural tissue integrity , were found in the right cunues, right calcarine, the inside of left fron-tal gyrus, left anterior cingulate cortex, left limbic central gyrus, right prefrontal cortex, right lingual gyrus, right posterior cingulated and left precentral gyrus (P <0.001).Conclusion The reduction of FA values in brain suggests white matter microstructure of patients with MDD was impaired .
Keywords：depressiondiffusion tensor imagingvoxel -based analysisfractional anisotropy
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 12-15 )