The polymorphisms of Pvu Ⅱ and Xba Ⅰ genes of the estrogen receptor in women with postpartum depression disorder
XIA Guang-yuan
ZHANG Jing
XIE Yuan
CHEN Jing
ZOU Tao
Abstract：Objective To investigate the correlation between the polymorphisms of estrogen receptor -α(ERα) and postpartum depression disorder (PPD), to provide genetic evidences for the etiology and pathogenesis of PPD , ant to provide the theory basis for diagnosis and therapy for PPD .Methods 45 cases (depressed group) and 45 controls (con-trol group) were selected according questionnaires .PCR -RFLP was applied to examine the polymorphisms of Pvu Ⅱ and XbaⅠ in ERα.Allele frequency was assessed using genetic numeration .The correlations between the polymorphisms of PvuⅡ and XbaⅠ and PPD using SPSS 18.0.Results The chi -square test revealed that the genotype distributions of PvuⅡ in ERαin depressed group and control group were significantly different , so were the allele frequencies (P and p, P <0.05).There was no significant different in genotype distribution or allele frequency (X and x) of XbaⅠ in ERαbe-tween depressed group and control group (P >0.05).Conclusion There is correlation between polymorphism of ER αPvuⅡ and PPD, while no correlation between genetic mutation of Xba Ⅰ and PPD is revealed.The analysis of the joint genotype shows that the general genotype distributions in depressed group and control group are similar .
Keywords：postpartum depression disorderestrogen receptor -αgene polymorphismsXba ⅠPvu Ⅱ
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 8-11 )