Determining the pharmacodynamic parameters of vecuronium in tuberculosis patients with different genders

LIU Min-qiang; WANG Hua; LI Ren-zhai; MA Ming-fei; LI Wei; DING Lan-lan; HE Ren-liang

doi:10.3969/j.issn.1001-9448.2014.18.012

Abstract：Objective To determine the pharmacodynamic parameters of vecuronium in tuberculosis patients with different genders.Methods Eighty patients ( ASA gradeⅠorⅡ) received selective general anesthesia were enrolled in this study, and divided into tuberculosis group ( Group T) and non-tuberculosis group ( Group N) .They were further di-vided into male groups ( Group TM and NM) and female groups ( Group TF and NF) .Each patient received intravenous injection of midazolam by 0.1 mg/kg, fentanyl by 4 μg/kg, and propofol with target plasma concentration of 1~3 μg/mL.The neuromuscular block efficacy was measured by neuromuscular transmission monitor after patients'consciousness disappeared.With an intravenous vecuronium by 0.1 mg/kg, the responses were defined in terms of the percentages of maximum suppression at the first ( T1 ) of the train-of-four ( TOF) of the adductor pollicis muscle.Endotracheal intu-bation was conducted when T1 fell to its lowest and repeated no less than 3 times.The onset time, the maximum inhibition of T1 , the clinical effect time, the recovery index, the pharmacological effect time and the endotracheal intubation condi-tions were recorded.MAP and HR were measured before anesthesia induction ( t0 ) , and 5 min ( t1 ) , 15 min ( t2 ) , 30 min ( t3 ) , 45 min ( t4 ) , and 1 h ( t5 ) after general anesthesia.Results Compared with Group N, the clinical effect time of vecuronium in Group T was significantly shorter ( P<0.05 ) , but there was no significant difference between genders (P>0.05).However, the clinical effect time of vecuronium in Group NF was longer than Group NM (P<0.05).No statistical difference was found in the maximum inhibition of T1 , the onset time, the recovery index, the pharmacological effect time, the endotracheal intubation conditions or, hemodynamics before or after anesthesia induction among the four groups.Conclusion Anesthesiologists could neglect the consequence of blocking aging of vecuronium in tuberculosis pa-tients with different gender.