Comparison of synaptophysin expression in hippocampus between Balb/c and C57BL/6 mice
HAO Yan-li
HUANG Xin-yan
XU Li-ping
YANG Dan-di
DONG Wei-ren
Abstract：Objective To compare the differences of synaptophsin expression in hippocampus between Balb/c mice and C57BL/6 mice.Methods Each 10 Balb/c mice and 10 C57BL/6 mice were used, which were fixed with the cardiac perfusion with paraformaldehyde for brain tissue collection.The brains were scliced with Cryostat Microtome.Le-vels of synaptophsin expression in various subregion of hippocampus in Balb/c mice and C57BL/6 mice were compared using immunostaining.Results Synaptophsin was expressed in the hippocampus of Balb/c mice and C57BL/6 mice, and there was a strain difference.Compared to Balb/c mice, there was a higher expression level of synaptophysin in the stra-tum of pyramidal cells in CA1 of hippocampus and a lower expression level of synaptophysin in the stratum of pyramidal cells in CA3 of hippocampus in C57BL/6 mice.Conclusion The difference of synaptaphysin expression in hippocampus between C57BL/6 mice and Balb/c mice may be correlated with their behavioral difference.
Keywords：synaptophysinhippocampusBalb/c mouseC57BL/6 mousestrain difference
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 2652-2654,2655 )