Short-term efficacy comparison between from Chinese type Ⅰ donation and cadaveric donation for kidney transplantation

LEI Xue-zhi; HU Jian-min; XU Xiao-long; LI Min; ZHAO Ming

doi:10.3969/j.issn.1001-9448.2014.16.018

Abstract：Objective To compare the short -term clinical efficacy after kidney transplantation between from Chinese type Ⅰdonation and cadaveric donation .Methods We retrospectively analyzed the clinical outcomes within 6 months after kidney transplantation of 34 cases from donation after brain death ( DBD) and 55 from cadaveric kidney were retrospectively analyzed.The serum creatinine (Scr) 1, 2, 4, 12 and 24 weeks after transplantation were recorded , so were the occurrence of delayed graft function ( DGF) , complications , and recovery time of graft function after DGF .Re-sults The Scr levels were significantly lower in DBD group than in cadaveric donor group 1 and 2 weeks after transplanta-tion (P<0.05), but there was no significant difference 4, 12 or 24 weeks after transplantation (P>0.05).The inci-dence rates of DGF were 11.8%and 16.4%in DBD and cadaveric donor groups , respectively , with no significant differ-ence between these two groups ( P>0.05 ) .The recovery time of graft function after DGF in DBD and cadaveric donor groups were (10.25 ±7.85) and (28.56 ±13.56) d, respectively, with significant difference between them (P<0.05). Grafts were all survived within 6 months in DBD group, and survival time in cadaveric donor group was (177.85 ±15.91) d, but there was no significant difference between them (P>0.05).The incidence of perioperative infection was 42.4%in DBD group, which was significantly higher than 18.2%in cadaveric donor group (P<0.05).Conclusion Compare with traditional cadaveric donation , kidney transplantation from DBD donors shows favorable short -term recovery in term of graft function , and short duration of DGF recovery , but with higher incidence of perioperative infection .