Comparison of effects of recombinant human granulocyte/macrophage colony stimulating factor and nano-silver on the recovery of degreedⅡdeep burn
YANG Jing-zhe
CHEN Feng-ping
GENG Qi-ying
FENG Xin-shu
WEN Hai-lin g
Abstract：Objective To compare the effects of recombinant human granulocyte /macrophage colonystimulating factor (rhGM-CSF) and nano-silver as treatment for degreed Ⅱdeep burn.Methods The degreedⅡdeep burn mod-el were constructed with Wistar rats , which were randomly divided into 3 groups, petrolatum treatment ( Group A, n=30), nano-silver treatment (Group B, n=30) and rhGM-CSF treatment (Group C, n=30).The inflammatory reac-tion, healing rate and culture bacteria on wound were observed on the 1st, 4th, 7th, 10th, 14th and 21st day after treatment. Results Vasculization and epithelizaiton were observed in all the 3 groups on the 10 th day.Obvious redness and swollen were observed in Group A , with abscess under scab and infiltrated subcutaneously , and mass inflammatory cells , in-creased vascular penetration and slow vasculizatoin and epitheliztion were also observed .These were suppressed in Group B and C.Significantly highest healing rates were observed in Group C , followed by Group B and Group A on the 14th and 21st day (P<0.05).Bacteria were found in Group A and B on the 4th day, while on the 10th day in Group C.Significant-ly less bacteria were observed in Group B or C than those in Group A on the 10th, 14th and 21st day (P<0.05), while there was no significant difference between Group B and C (P>0.05).Conclusion The rhGM-CSF and nano-silver treatment can reduce bacteria growth and alleviate inflammatory reaction .And rhGM-CSF provides better efficacy on pro-moting wound healing than nano -silver.
Keywords：recombinant human granulocyte -macrophage colony stimulating factornano silverburn woundbacteria
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 2511-2514 )