Retrospective analysis of the diagnosis of patients with positive aquaporin-4 antibody
HE Yi-hua
LONG You-ming
YANG Xin-guang
YANG Ning
FANG Yong-xiang
YIN Jian-rui
PU Shu-xiang
GAO Qing-chun
GAO Cong
Abstract：Objective To analyze the diagnosis of patients with positive aquaporin -4 (AQP4) antibody, and to re-evaluate the previous diagnosis , thus to provide evidences for diagnosis and treatment for patients with neuromyelitis optica ( NMO) and NMO spectrum disorder ( NMOSD) .Methods AQP4 antibodies were tested by an indirect immuno-fluorescence assay employing HEK -293 cells transected with recombinant human AQP 4.Clinical diagnoses were retro-spectively analyzed.Results A total of 139 patients with positive AQP4 antibody were included.In the initial episode, NMO, multiple sclerosis ( MS) , optic neuritis ( ON) , transverse myelitis ( TM) and the other diagnosis were diagnosed in 7 (5%), 20 (14.4%), 39 (28.1%), 59 (42.4%) and 14 (10.1%) patients, respectively.In the follow-up, ac-cording to revised diagnosis, NMO, MS, ON, TM and other disorders were diagnosed in 33 (23.7%), 68 (48.9%), 8 (5.8%), 28 (20.1%) and 2 (1.4%) patients, respectively.The final diagnosis showed that 88 patients diagnosed as NMO and 51 patients as NMOSD, including 7 patients (13.7%) with recurrent ON, 39 patients (76.5%) with recurrent TM and 5 patients (9.8%) with other lesions in brain.Conclusion Patients with positive AQP4 antibody are usually misdiagnosed as MS .
Keywords：aquaporin-4neuromyelitis opticamultiple sclerosismyelitisdiagnosis
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 2495-2497 )