Magnetic resonance imaging feature predicts the conversion in clinically isolated syndrome with pure brainstem lesions
YANG Ning
LONG You-ming
FAN Yong-xiang
SHAN Fu-lan
XIE Long-chang
YIN Jian-rui
PU Shu-xiang
GAO Qing-chun
GAO Cong
Abstract：Objective To explore the MRI features of brainstem lesions in clinically isolated syndromes ( CIS) and evaluated their association with clinical conversion .Methods Patients with brainstem CIS were prospectively fol-lowed-up and brain MRI features were retrospectively analyzed .Results A total of 25 patients were followed -up for a median of 65 months.Neuromyelitis optica ( NMO), NMO spectrum disorder ( NMOSD) and multiple sclerosis ( MS) were observed in 5, 4 and 4 cases, respectively.According to MRI,"Fog-like"lesions were significantly more abundant in NMO+NMOSD patients than in MS patients (P=0.001) or stable patients (P<0.000 1).Extensive lesions were on-ly found in 5 (55.6%) patients with NMO+NMOSD.Aqueduct lesions were also significantly more frequently found in NMO+NMOSD patients than in MS patients (P=0.021) or stable patients (P=0.002).The sensitivity and specificity of"Fog-like"lesions in T2 -weight image for diagnosis of NMO +NMOSD were 100% and 93.75%, respectively;while the sensitivity and specificity of extensive lesions for diagnosis of NMO +NMOSD were 55.56%and 100%, respec-tively.The sensitivity and specificity of aqueduct lesions for diagnosis of NMO +NMOSD were 77.78%and 93.75%, re-spectively.Conclusion The "Fog-like", extensive and aqueduct lesions in the brainstem in MRI are important early markers for future NMO and NMOSD .
Keywords：MRIclinically isolated syndromeneuromyelitis optica
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 2491-2494 )