Detection and the significance of aquaporin-4 antibody in patients with transverse myelitis
XIE Long-chang
SHAN Fu-lan
ZHENG Yang-bo
CHEN Meng-yu
YANG Jie
GAO Cong
YANG Ning
LONG You-ming
YANG Xin-guang
Abstract：Objective To evaluate the significance of AQP 4 antibody in patients with different types of transverse myelitis (TM).Methods Patients with TM were included retrospectively between 2003 and 2014.AQP4 antibodies were detected by an indirect immunofluorescence assay employing HEK -293 cells transected with recombinant human AQP4.Results A total of 92 patients were included , among whom 68 patients with longitudinal extensive transverse my-elitis (LETM) and 24 patients with non-LETM.Positive AQP4 was observed in 39 LETM (57.4%, 39/68) and 2 n-LETM (8.3%, 2/24) patients.The female ratio, LETM ratio, relapsing case and EDSS were significantly higher in AQP4 positive patients than those in negative ones .In the patients with LETM , significantly more female and relapsing ca-ses were observed in AQP4 positive subjects than negatives .Correlation analysis showed that female , LETM and recurrent TM were significantly positively correlated with AQP 4 antibody .Conclusion AQP4 antibody is mainly present in fe-males, and predicting high relapsing incidence .
Keywords：myelitismultiple sclerosisneuromyelitis opticaaquaporin-4
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 2488-2490 )