Efficacy of Yiqiyangyinliangxue method combined with telmisartan in treating patients with primary IgA ne-phropathy

CHEN Shu-juan; LUO Ren

Abstract：Objective To observe the efficacy and safety of Yiqiyangyinliangxue method combined with telmisar -tan in treating primary IgA nephropathy patients of Qi -Yin deficiency syndrome (QYDS).Methods Randomized and controlled trial was conducted in 61 IgA nephropathy patients of QYDS , who were randomly assigned to two groups treated with traditional Chinese medicine (TCM) combined with Telmisartan (treatment group, n =31) and telmisartan alone (control group, n=30) for 8weeks.The changes of TCM syndrome score , 24-hour urine protein quantity (UP), urina-ry red blood cell (uRBC), serum creatinine (Scr), blood urea nitrogen (BUN), IgA concentration were recorded .Re-sults According to the curative criteria of TCM and Western medicine , the total effective rates were 80.6%and 71.0%, respectively, in treatment group, which were higher than control group (40.0%, P<0.001;63.3%, P>0.05).Com-pared with those before treatment ) , The UP and TCM syndrome scores were significantly improved in both groups after 4-week treatment (P<0.01), which was significantly more prominent in treatment group (P<0.05).The levels of uRBC, Scr and IgA were also significantly reduced in treatment group compared with control group 8 weeks after treatment ( P<0.05).Conclusion Yiqiyangyinliangxue method combined with telmisartan can more effectively reduce UP , uRBC, Scr, IgA and the TCM syndrome scores .