Correlation between 24-hour urine protein and hypothyroidism in patients with severe pre-eclampsia

Abstract：Objective To study correlation between 24-hour urine protein and hypothyroidism in patients with severe pre-eclampsia.Methods A total of 178 patients with severe pre -eclampsia (S-PE), among which 69 cases ( TSH>3.3 mU/L) were served as hypothyroidism group and 109 S-PE cases with normal TSH ( TSH 0.3~3.3 mU/L) were selected as normal group , were included;while 268 healthy women with matched pregnancy stage and age with nor-mal blood pressures and no obstetrics complications were selected as controls .Thyroid hormones ( TSH, FT3 and FT4 ) and serum albumin were measured , and so was the 24-hour urine protein in patients with S -PE.Results The FT3 and FT4 in hypothyroidism group and normal group were significantly lower than control group ( P<0.01 ) .Significantly higher 24-hour urine protein was observed in hypothyroidism group than normal group (P<0.01).Moreover, there was signifi-cantly higher 24-hour urine protein in early -onset preeclampsia ( EOP) than late-onset preeclampsia ( LOP) patients (P<0.05).In the S-PE group, TSH was significantly positively correlated with 24-hour urine protein (r=0.26, P=0.001), and negatively correlated with serum albumin (r=-0.23, P=0.002); and FT4 was significantly negatively correlated with 24-hour urine protein (r=-0.17, P=0.023), and positively correlated with serum albumin (r=0.22, P=0.003).There was no significant correlation between FT 3 and 24 -hour urine protein ( r =-0.07, P=0.340).There was significantly positive correlation between FT 3 and serum albumin (r=0.35, P=0.000).Conclusion Hypothyroidism in patients with S -PE elevates the 24-hour urine protein , which is correlated with the severity of hy-pothyroidism .Thyroid hormone levels in patients with pre -eclampsia can be applied as monitoring indicators for renal function.