Effects of low-molecular-weight citrus pectin in combination with endostatin on the growth and liver metastasis of oxaliplatin-resistant colon cancer in mice
YANG Guo-hua
XU Peng
LIU Hai-ying
Abstract：Objective To study the inhibitory effects of low -molecular-weight citrus pectin ( LCP) in combi-nation with endostatin (ES) on tumor growth and liver metastasis in oxaliplatin -resistant colon cancer mouse model . Methods Liver metastasis model of mouse exogenic colon carcinoma were established and treatd treated by oral LCP or /and ES injection .Diameters of primary implanted spleen tumor and numbers of liver metastatic nodes were observed and tumor microvessel density ( MVD) counts were calculated 3 weeks after model established .Results Oral LCP inhibited angiogenesis , tumor growth and liver metastasis of exogenic colon cancer , while ES given alone also reduced tumor angio-genesis.Combination of LCP and ES significantly increased the inhibitory effects of tumor angiogenesis and liver metasta -ses.Conclusion Combination of LCP and ES significantly inhibits oxaliplatin -resistant colon cancer growth and liver metastasis via reduction of angiogenesis .
Keywords：colon cancerliver metastasisdrug resistanceLCPendostatin
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 1309-1312 )