Fetal aneuploidy screening using frontomaxillary facial angle at 11-13 +6 weeks
LUO Qing
WAN Jun-hui
DAI Chang-ping
XIAO Qing-hua
JIANG Jin-xiong
CAO Xiao-zhen
Abstract：Objective To evaluate the significance of frontomaxillary facial ( FMF) angle at 11-13 +6 week ges-tation in the prediction of fetal aneuploidy .Methods Possible differences of FMF angle between the groups of fetal eu-ploidy (n=627) and aneuploidy (n=31) were tested in southern China.A regression model was used to assess the cor-relation between the FMF angle and NT , free-hCG MoM, and PAPP-A MoM.Specificity and sensitivity of FMF angle for fetal aneuploidy were assessed using the receiver operating characteristic ( ROC) curve.Results In aneuploidy group, FMF was significantly greater (91.5 ±5.0) °vs (82.6 ±3.9) °, P<0.05) than that of normal group .There was no significant association between the FMF angle and NT (r =0.006, P=0.843), maternal serum PAPP -A (r =0.016, P=0.802) or maternal serum fβ-hCG (r=0.109, P=0.841) in euploid fetuses.Based on the ROC curve a-nalysis, the best cut off value of FMF angle for indicating fetal aneuploidy was 88.6°with a sensitivity of 68.4%and a specificity of 81.4%.The area under the curve was 0.776.Conclusion FMF angle can be a useful complementary first trimester markers for fetal aneuploidy .
Keywords：frontomaxillary facial anglefirst trimesterultrasoundROCaneuploidy
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 1173-1175 )