Comparison of GFR calculation methods：99m Tc-DTPA renal dynamic imaging, abbreviated MDRD and CKD-EPI equations in patients with chronic kidney disease
ZENG Feng-wei
LI Jian-fang
XIE Liang-jun
ZHANG Feng
PENG Xiao-lin
WU Chun-xing
CHENG Mu-hua
Abstract：Objective To compare the applications of renal dynamic imaging with 99m Tc-DTPA ( Gates′met-hod), abbreviated MDRD (aMDRD) equation and CKD-EPI equation in renal function assessment in the patients with chronic kidney disease ( CKD) .Methods A total of 159 adult patients with CKD were included .The glomerular filtra-tion rate (GFR) obtained by Gates′method, aMDRD equation and CKD-EPI equation against 99mTc-DTPA dual plasma clearance ( rGFR) with Pearson correlational analyses and Bland -Altman method were performed .Results A statistical-ly significant correlation was found between rGFR and Gates′method (r=0.900, P<0.001), which was higher than aM-DRD formula (r=0.816, P<0.001) and CKD-EPI formula (r=0.825, P<0.001).Bland-Altman analysis showed that all equations underestimated the rGFR in the overall performance , but Gates′method had less bias [ -3.4 mL/( min· 1.73 m2 ) ] , good precision [ 11.8 mL/( min · 1.73 m2 ) ] , and greatest accuracy within ±30% of rGFR (71.7%) than aMDRD and CKD-EPI equations.In each stage of CKD, excepting patients in Stage 1 Stage 2, a statisti-cally significant higher accuracy within ±30%was found of the Gates′method compared to the accuracy of the aMDRD formula or CKD-EPI formula (P<0.05).No difference between the accuracies of the aMDRD formula and the CKD -EPI formula was found (P>0.05).Conclusion All three methods underestimate the rGFR, the new CDK-EPI equa-tion performs no better than aMDRD equation .Both equations can′t provide as much accuracy as Gates′method.
Keywords：glomerular filtration raterenal dynamic imagingabbreviated MDRD equationCKD-EPI equa-tiondual plasma sample method
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 1012-1016 )