The effects of Hawthorn leaves flavonoids on the cerebral PI3K/Akt signaling pathway in rats with cerebral ische-mia
ZHAO Lei
ZHANG Xiao-hong
WU Bo-cheng
WU Xiao-guang
DU Luan-ying
CHEN Xiao-ning
Abstract：Objective To study the effects of Hawthorn leaves flavonoids ( HLF) on the PI3K/Akt signaling pathway in rats with cerebral ischemia .Methods Chronic cerebral ischemia rat model was constructed by bilateral carot-id artery ligation.PI3K and Akt protein expression was assessed by immunohistochemical assay .Water content of brain tissue was detected by dry-wet method , while brain barrier permeability was measured by formamide method blood .Re-sults Compared with the model group , significant up-regulations in PI3K and Akt proteins were observed in Ginkgo bi-loba group and HLF group (P<0.05).Significant reductions in cerebral water content and EB content were also observed (P<0.05).Conclusion HLF can protect the brain from ischemia injury , probably via regulation of PI3K/Akt signaling pathway .
Keywords：Hawthorn leaves flavonoidsPI3K/Akt signaling pathwaycerebral ischemia
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 982-984 )