Effects of Breviscapine on the Na+, K+-ATPase activity in kidney tissues of rats with contrast-induced acute kidney injury
CHEN Zi-jie
SHI Li
CHEN Xi
JIANG Xiao-fei
Abstract：Objective To study the effects of Breviscapine on the Na +, K+-ATPase activity in kidney tissues of rats with contrast-induced acute kidney injury .Methods SD rats and diabetic rat models were randomly divided into five groups:normal control group (Group NS), contrast media control group (Group CM), Bre treatment group (Group Bre), diabetic model with contrast media group (Group DCM), and diabetic model with Bre treatment group (Group DBre) .Localization and activity of Na +, K+-ATPase in kidney tissues was detected by immunohistochemistry staining method.Results The activity of Na +, K+-ATPase in kidney tissues, which was inhibited by contrast media , was sig-nificantly enhanced with breviscapine ( P<0.05) , and it was significantly more prominent in diabetic rats ( Group DCM and DBre) (P<0.01).Conclusion Breviscapine provides a certain protection on contrast -induced acute kidney injury in rats, probably via lightening the inhibition of Na +, K+-ATPase activity caused by contrast media .
Keywords：contrast mediaacute kidney injuryBreviscapineNa+K+-ATPase
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 978-981 )